Publications
2024
Kim EJ, Jeon HB, Kang MJ,* Lee J* "Dynamic imaging of lipid droplets in cells and tissues by using dioxaborine barbiturate-based fluorogenic probes"
Anal. Chem. 2024, 96, 8356-8364. (*co-corresponding authors)
The Atomwise AIMS Program (Wallack et al.) "AI is a viable alternative to high throughput screening: a 318-target study" Sci. Rep. 2024, 14, 7526.
2023
Park JE**, Lee J**, Ok S, Byun S, Yoon SE, Kim YJ, Kang MJ "Wg/Wnt1 and Erasp link ER stress to proapoptotic signaling in an autosomal dominant retinitis pigmentosa model" Exp. Mol. Med. 2023, 55, 1544-1555 (**co-first authors)
Song D**, Lee JY**, Park EC, Choi NE, Nam HY, Seo J*, Lee J* "Structure-activity relationship analysis of activity-based probes targeting HTRA family of serine proteases" Bioorg. Med. Chem. Lett. 2023, 87, 129259 (**co-first authors, *co-corresponding authors)
2022
Choi NE, Kim EJ, Lee J. "A fluorescent molecular rotor for the in situ imaging of latent fingerprints" RSC Adv. 2022, 12, 33180-33186
Kim S**, Lee JY**, Choi J, Nam HY, Seo J*, Lee J* "Structure-activity relationship of mitochondria-targeting peptoids" Pept. Sci. 2022, 114, e24239. (**co-first authors & *co-corresponding authors)
2021
Manh NV, Hoang V, Ngo VTH, Ann J, Jang T-H, Ha J-H, Song JY, Ha H-J, Kim H, Kim Y-H, Lee J, Lee J. "Discovery of highly potent human glutaminyl cyclase (QC) inhibitors as anti-Alzheimer's agents by the combination of pharmacophore-based and structure-based design" Eur.J.Med.Chem. 2021, 226, 113819.
Kim TH, Morshed MN, Londhe AM, Lim JW, Jung SY, Yang H, Cho S, Cho SJ, Hwang H, Lim SM, Lee JY, Lee J*, Pae AN* "The translocator protein ligands as mitochondrial functional modulators for the potential anti-Alzheimer agents" J. Enzyme Inhib. Med. Chem. 2021, 36, 831-846 (*co-corresponding authors)
Choi NE, Lee JY, Park EC, Lee JH, Lee J. "Recent advances in organelle-targeted fluorescent probes" Molecules 2021, 26, 217.
2020
Nam HY, Choi J, Kumar SD, Nielsen JE, Kyeong M, Wang S, Kang D, Lee Y, Lee J, Yoon MH, Hong S, Lund R, Jenssen H, Shin SY, Seo J. "Helicity modulation improves selectivity of antimicrobial peptoids" ACS Infect. Dis. 2020, 6, 2732-2744
Nam, H.Y.**; Song, D.**; Eo, J.**; Choi, N-E.; Hong, J-A.; Hong, K.T.; Lee, J-S.; Seo, J.*; Lee, J.* "Activity-based probes for the high temperature requirement A serine proteases." ACS Chem. Biol. 2020, 15, 2346-2354 (**co-first authors and *co-corresponding authors)
Lim JW, Lee J,* Pae AN.* "Mitochondrial dysfunction and Alzheimer's disease: prospects for therapeutic intervention." BMB Rep. 2020, 53, 47-55. (*co-corresponding authors)
Kim S, Nam HY, Lee J,* Seo J.* "Mitochondrion-Targeting Peptides and Peptidomimetics: Recent Progress and Design Principles." Biochemistry 2020, 59, 270-284. (*co-corresponding authors)
2019
Hoang VH, Ngo VTH, Cui M, Manh NV, Tran PT, Ann J, Ha HJ, Kim H, Choi K, Kim YH, Chang H, Macalino SJY, Lee J, Choi S, Lee J. "Discovery of Conformationally Restricted Human Glutaminyl Cyclase Inhibitors as Potent Anti-Alzheimer's Agents by Structure-Based Design." J. Med. Chem. 2019, 62, 8011-8027.
Yoon S, Kim SE, Kim JH, Yoon I, Tran PT, Ann J, Kim C, Byun WS, Lee S, Kim S, Lee J,* Lee J.* "Structure-activity relationship of leucyladenylate sulfamate analogues as leucyl-tRNA synthetase (LRS)-targeting inhibitors of Mammalian target of rapamycin complex 1 (mTORC1)." Bioorg. Med. Chem. 2019, 27, 1099-1109. (*co-corresponding authors)
2018
Elkamhawy A, Park JE, Hassan AHE, Pae AN, Lee J, Paik S, Park BG, Roh EJ. "Pyrazinyl ureas revisited: 1-(3-(Benzyloxy)pyrazin-2-yl)-3-(3,4-dichlorophenyl)urea, a new blocker of Aβ-induced mPTP opening for Alzheimer's disease." Eur. J. Med. Chem. 2018, 157, 268-278.
Yoon S, Zuo D, Kim JH, Yoon I, Ann J, Kim SE, Cho D, Kim WK, Lee S, Lee J, Kim S, Lee J. " Discovery of novel leucyladenylate sulfamate surrogates as leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors." Bioorg. Med. Chem. 2018, 26, 4073-4079.
Ngo, V.T.H.; Hoang, V.; Tran, P.; Van Manh N.; Ann, J.; Kim, E.; Cui, M.; Choi, S.; Lee, J.; Kim, H.; Ha, H.; Choi, K.; Kim, Y.; Lee, J. “Potent human glutaminyl cyclase inhibitors as potential anti-Alzheimer's agents: Structure-activity relationship study of Arg-mimetic region” Bioorg. Med. Chem. 2018, 26, 3133-3144
Nam, H.Y.*; Hong, J.A.*; Choi, J.; Shin, S.; Cho, S.K.; Seo, J.; Lee, J. "Mitochondria-targeting peptoids" Bioconj. Chem. 2018, 29, 1669-1676. (*Co-first authors)
Hong, J.A.; Kim, M.J.; Eoh, J.; Lee, J. “A turn-on fluorescent probe for live cell imaging of biothiols” Bull. Kor. Chem. Soc. 2018, 39, 425-426.
Ngo, V.T.H.; Hoang, V.; Tran, P.; Ann, J.; Cui, M.; Park, G.; Choi, S.; Lee, J.; Kim, H.; Ha, H.; Choi, K.; Kim, Y.; Lee, J. “Potent human glutaminyl cyclase inhibitors as potential anti-Alzheimer's agents: Structure-activity relationship study of Arg-mimetic region” Bioorg. Med. Chem. 2018, 26, 1035-1049.
Kim, S.M.; Lee, M.; Lee, S.Y.; Lee, S.M.; Kim, E.J.; Kim, J.S.; Ann, J.; Lee, J.; Lee, J. “Synthesis and biological evaluation of 3-(2-aminoethyl) uracil derivatives as gonadotropin-releasing hormone (GnRH)receptor antagonists” Eur. J. Med. Chem. 2018, 145, 413-424.
Elkamhawy, A.; Park, J.E.; Hassan, A.H.; Pae, A.N.; Lee, J.; Park, B.G.; Roh, E.J. “Synthesis and evaluation of 2-(3-arylureido)pyridines and 2-(3-arylureido)pyrazines as potential modulators of Aβ-induced mitochondrial dysfunction in Alzheimer's disease.” Eur. J. Med. Chem. 2018, 144, 529-543.
Lee, J.; Kang, D.; Choi, J.; Huang, W.; Wadmen, M.; Barron, A.E.; Seo, J. “Effect of side chain hydrophobicity and cationic charge on antimicrobial activity and cytotoxicity of helical peptoids” Bioorg. Med. Chem. Lett. 2018, 28, 170-173.
Ha, H.; Kang, D.W.; Kim, H.M.; Kang, J.M.; Ann, J.; Hyun, H.J.; Lee, J.H.; Kim, S.H.; Kim, H.; Choi, K.; Hong, H.S.; Kim, Y.H.; Jo, D.G.; Lee, J.; Lee, J. “Discovery of an Orally Bioavailable Benzofuran Analogue that Serves as a β-amyloid Aggregation Inhibitor for the Potential Treatment of Alzheimer's Disease.” J. Med. Chem. 2018, 61, 396-402.
2017
Park, J.E.; Elkamhawy, A.; Hassan, A.H.; Pae, A.N.; Lee, J.; Paik, S.; Park, B.G.; Roh, E.J. “Synthesis and evaluation of new pyridyl/pyrazinyl thiourea derivatives: Neuroprotection against amyloid-β-induced toxicity.” Eur. J. Med. Chem. 2017, 141, 322-334.
Kim, T.H.; Son, W.S.; Morshed, M.N.; Londhe, A.M.; Jung, S.Y.; Park, J.; Park, W.K.; Lim, S.M.; Park, K.D.; Cho, S.J.; Jeong, K.S.; Lee, J.*; Pae, A.N.* “Discovery of thienopyrrolotriazine derivatives to protect mitochondrial function against Aβ-induced neurotoxicity.” Eur. J. Med. Chem. 2017, 141, 240-256 (*co-corresponding authors)
Hong, J.A.; Choi, N.E.; La, Y.K.; Nam, H.Y.; Seo, J.; Lee, J. “Development of a smart activity-based probe to detect subcellular activity of asparaginyl endopeptidase in living cells.” Org. Biomol. Chem. 2017, 15, 8018-8022.
Park, I.; Viswanath, A.N.I.; Park, B.G.; Jung, S. Y.; Park, K. D.; No, K. T.; Lee, J.; Pae, A.N. “Discovery of Non-Peptidic Small Molecule Inhibitors of Cyclophilin D as Neuroprotective Agents in Ab-induced Mitochondrial Dysfunction” J. Comput. Aided Mol. Des. 2017, 31, 929-941.
Yoon, S.; Kim, J.H.; Koh, Y.; Tran, P.T.; Ann, J.; Yoon, I.; Jang, J.; Kim, W.K.; Lee, S.; Lee, J.; Kim, S.; Lee, J. "Discovery of simplified leucyladenylate sulfamates as novel leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors." Bioorg. Med. Chem. 2017, 25, 4145-4152
Elkamhawy, A.; Park, J.E.; Hassan, A.H.; Pae, A.N.; Lee, J.; Park, B.G.; Paik, S.; Do, J.; Park, J.H.; Park, K.D.; Moon, B.; Park, W.K.; Cho, H.; Jeong, D.Y.; Roh, E.J. "Design, synthesis, biological evaluation and molecular modelling of 2-(2-aryloxyphenyl)-1,4-dihydroisoquinolin-3(2H)-ones: A novel class of TSPO ligands modulating amyloid-β-induced mPTP opening." Eur. J. Pharm. Sci. 2017, 104, 366-381
Hoang, V.; Tran, P.; Cui, M.; Ngo, V.T.H.; Park, J.; Choi, S.; Lee, J.; Choi, K.; Cho, H.; Kim, H.; Ha, H.; Hong, H.; Kim, Y.; Lee, J. “Discovery of Potent Human Glutaminyl Cyclase Inhibitors as Anti-Alzheimer’s Agent Based on Rational Design” J. Med. Chem. 2017, 60, 2573-2590
Elkamhawy, A.; Park, J.E.; Hassan, A.H.; Ra, H.; Pae, A.N.; Lee, J.; Park, B.G.; Moon, B.; Park, H.M.; Roh, E.J. "Discovery of 1-(3-(benzyloxy)pyridin-2-yl)-3-(2-(piperazin-1-yl)ethyl)urea: A new modulator for amyloid beta-induced mitochondrial dysfunction." Eur. J. Med. Chem. 2017, 128, 56-69
Kim, T.H.; Yang, H.Y.; Park, B.G.; Jung, S.Y.; Park, J.H.; Park, K.D.; Min, S.J.; Tae, J.; Yang, H.; Cho, S.; Song, H.; Mook-Jung, I.; Lee, J.*; Pae, A.N.* “Discovery of Benzimidazole Derivatives as Modulators of Mitochondrial Function: A Potential Treatment for Alzheimer’s Disease” Eur. J. Med. Chem. 2017, 125, 1172-1192 (*co-corresponding authors)
2016
Yoon, S.; Kim, J.H.; Kim, S.; Jang, J.; Kim, S.; Moon, H.; Kim, W.; Lee, S.; Lee, J.; Kim, S.; Lee, J. “Discovery of leucyladenylate sulfamates as novel leucyl-tRNA (LRS)-targeted mTORC1 inhibitors” J. Med. Chem. 2016, 59, 10322-10328.
Kim, SM; Lee, M; Lee, SY; Park, E; Lee, SM; Kim, EJ; Han, MY; Yoo, T; Ann, J; Yoon, S; Lee, J; Lee, J "Discovery of an Orally Bioavailable Gonadotropin-Releasing Hormone Receptor Antagonist." J. Med. Chem. 2016, 59, 9150-9172
Cho, N.C.; Seo, S.H.; Kim, D.;Shin, J.S.; Ju, J.; Seong, J.; Seo, S.H.; Lee, J.; Lee, K.T.; Kim, Y.K.; No, K.T.; Pae, A.N. "Pharmacophore-based virtual screening, biological evaluation and binding mode analysis of a novel protease-activated receptor 2 antagonist" J. Comput .Aided Mol. Des. 2016, 8, 625-37.
La, Y.K.; Hong, J.A.; Jeong, Y.J.; Lee, J. " A 1,8-naphthalimide-based chemosensor for dual-mode sensing: Colorimetric and fluorometric detection of multiple analytes" RSC Adv. 2016, 6, 84980-84105
Yoon, S; Kim, J. H.; Yoon, I.; Kim, C.; Kim, S.E.; Koh, Y.; Jeong, S.J.; Lee, J.; Kim, S.; Lee, J. "Discovery of (S)-4-isobutyloxazolidin-2-one as a novel leucyl-tRNA synthetase (LRS)-targeted mTORC1 inhibitor." Bioorg. Med. Chem. Lett. 2016, 26, 3038-3041
Lee, J. "Mitochondrial drug targets in neurodegenerative diseases", Bioorg. Med. Chem. Lett. 2016, 26, 714-720
Lee, H.R.; Farhanullah; Lee, J.; Jajoo, R.; Kong, S.Y.; Shin, J.Y.; Kim, J.O.; Lee, J.; Lee J.; Kim, H.J. “Discovery of a Small Molecule that Enhances Astrocytogenesis by Activation of STAT3, SMAD1/5/8, and ERK1/2 via Induction of Cytokines in Neural Stem Cells.” ACS Chem. Neurosci. 2016, 7, 90-99
2015
Cho, N.C.; Cha, J.H.; Kim, H.; Kwak, J.; Kim, D.; Seo, S.H.; Shin, J.S.; Kim, T.; Park, K.D.; Lee, J.; No, K.T.; Kim, Y.K.; Lee, K.T.; Pae, A.N. “Discovery of 2-aryloxy-4-amino-quinazoline derivatives as novel protease-activated receptor 2 (PAR2) antagonists.” Bioorg. Med.Chem. 2015, 23, 7717-7727
Choi K, Lim KS, Shin J, Kim SH, Suh YG, Hong HS, Kim H, Ha HJ, Kim YH, Lee J, Lee J. "6-Phenoxy-2-phenylbenzoxazoles, novel inhibitors of receptor for advanced glycation end products (RAGE)" Bioorg. Med. Chem. 2015, 23, 4919-4935
La, Y. K.; Choi, N. E.; Chung, S.; Lee, J. "Thiophene‐substituted Aza‐BODIPYs as Near‐Infrared Fluorophores" Bull. Kor. Chem. Soc. 2015, 36, 1747-1748
Lee J, Huang W, Broering JM, Barron AE, Seo J. "Prostate tumor specific peptide-peptoid hybrid prodrugs" Bioorg. Med. Chem. Lett. 2015, 25, 2849-2952
Nam M, Kim T, Kwak J, Seo SH, Ko MK, Lim EJ, Min SJ, Cho YS, Keum G, Baek DJ, Lee J,* Pae AN.* "Discovery and biological evaluation of tetrahydrothieno[2,3-c]pyridine derivatives as selective metabotropic glutamate receptor 1 antagonists for the potential treatment of neuropathic pain" Eur. J. Med. Chem. 2015, 97, 245-258 (*co-corresponding author)
Cho GH, Kim T, Son WS, Seo SH, Min SJ, Cho YS, Keum G, Jeong KS, Koh HY, Lee J,* Pae AN.* "Synthesis and biological evaluation of aryl isoxazole derivatives as metabotropic glutamate receptor 1 antagonists: a potential treatment for neuropathic pain" Bioorg. Med. Chem. Lett. 2015, 25,1324-1328 (*co-corresponding author)
2014
Elkamhawy A, Lee J, Park BG, Park I, Pae AN, Roh EJ. "Novel quinazoline-urea analogues as modulators for Aβ-induced mitochondrial dysfunction: design, synthesis, and molecular docking study" Eur. J. Med. Chem. 2014, 84, 466-75
2013
Choi, M. J.; Thorat, D. A.; Jang, J. W.; Yang, H.; No, E. S.; Kim, S. J.; Lee, J.; Choo, H.; Lee, C. S.; Ko, S.Y.; Lee, J.; Nam, G. S.; Pae, A. N.“Synthesis and biological evaluation of aryloxazole derivatives as vascular disrupting agents for cancer therapy” J. Med. Chem. 2013, 56, 9008-9018
Yoon, H.J.; Kong, S.Y; Park, M.H.; Cho, Y.; Kim, S.E.; Shin, J.Y.; Jung, S.;Lee, J.; Farhanullah; Kim, H.J.; Lee, J. “Structure-activity relationship of human glutaminyl cyclase inhibitors having an N-(5-methyl-1H-imidazol-1-yl)propyl thiourea template” Bioorg. Med. Chem. 2013, 21, 7165-7174
Morell, M.; Nguyen, Duc T.; Willis, A.L.; Syed, S.; Lee, J.; Deu, E.; Deng, Y.; Xiao, J.; Turk, B.E.; Jessen, J.R.; Weiss, S.J.; Bogyo, M.“Coupling Protein Engineering with Probe Design To Inhibit and Image Matrix Metalloproteinases with Controlled Specificity.” J. Am. Chem. Soc. 2013, 135, 9139-9148
Tran, P.T.; Hoang, V.H.; Thorat, S.A.; Kim, S.E.; Ann, J.; Chang, Y.J.; Nam, D.W.; Song, H.; Mook-Jung, I.; Lee, J.; Lee, J. “Structure-activity relationship of human glutaminyl cyclase inhibitors having an N-(5-methyl-1H-imidazol-1-yl)propyl thiourea template” Bioorg. Med. Chem. 2013, 13, 3821-3830
Kang, B.; Chung, S.; Ahn, Y.D.; Lee, J.; Seo, J. “Porphyrin-Peptoid Conjugates: Face-to-Face Display of Porphyrins on Peptoid Helices” Org. Lett. 2013, 15, 1670-1673
Yang, H.Y.; Tae, J.; Seo, Y.W.; Kim, Y.J.; Im, H.Y.; Choi, G.D.; Cho, H.;Park, W-K.; Kwon, O.S.; Cho, Y.S.; Ko, M.; Jang, H.; Choi, K.; Kim, C-H.; Lee, J.*; Pae, A.N.* “Novel Pyrimidoazepine analogs as serotonin 5-HT2A and 5-HT2C receptor ligands for the treatment of obesity” Eur. J. Med. Chem. 2013, 63, 558-569 (*co-corresponding author)
Kim, Y.S.; Jung, S.H.; Park, B.G.; Ko, M.K.; Jang, H.S.; Choi, K.; Baik, J.H.; Lee, J.; Lee, J.K.; Pae, A.N.; Cho, Y.S.; Min, S.J. "Synthesis and evaluation of oxime derivatives as modulators for amyloid beta-induced mitochondrial dysfunction" Eur. J. Med. Chem. 2013, 62, 71-83
Lee, J.* Bogyo, M.* “Target Deconvolution Techniques in Modern Phenotypic Profiling” Curr. Opin. Chem. Biol. 2013, 17, 118-126 (*co-corresponding author)
Edgington, L.E.; Verdoes, M.; Ortega, A.; Withana, N.P.; Lee, J.; Syed, S.; Bachmann, M.H.; Blum, G.; Bogyo, M. “ Functional Imaging of Legumain in Cancer Using a New Quenched Activity-Based Probe” J. Am. Chem. Soc. 2013, 135, 174-182
2012
Kim, J; Lee, J; Moon, B; Mook-Jung, I; Nam, G; Keum, G; Pae, A.N.; Choo, H. “Pyridyl-urea Derivatives as Blockers of Abeta induced mPTP Opening for Alzheimer’s Disease” Bull. Korean Chem. Soc. 2012, 33, 3887-3889
Lee, J “Cobalt(III) Complexes as Novel Matrix Metalloproteinase-9 Inhibitors” Bull. Korean Chem. Soc. 2012, 33, 2762-2764
Cho, Y.; Kim, M.S.; Kim, H.S.; Ann, J.; Lee, J.; Pearce, L.V.; Pavlyukovets, V.A.; Morgan, M. A.; Blumberg, P.M.; Lee, J. “The SAR analysis of TRPV1 agonists with the a-methylated B-region” Bioorg. Med. Chem. Lett. 2012, 22, 5227-5231.
Lee, J.*; Bogyo, M.* “Synthesis and evaluation of aza-peptidyl inhibitors of the lysosomal asparaginyl endopeptidase, legumain” Bioorg. Med. Chem. Lett. 2012, 22, 1340-1343. (*co-corresponding author)
1999-2011
Ewald, S. E.; Engel, A.; Lee, J.; Wang, M.; Bogyo, M.; Barton, G. M. “ Nucleic acid recognition by Toll-like receptors is coupled to processing by cathepsins and asparagine endopeptidase.” J. Exp. Med. 2011, 208, 643-651.
Lee, J.; Bogyo, M. “Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain” ACS Chem.Biol. 2010, 5, 233-243.
Harney, A. S.; Lee, J.; Manus, L. M.; Wang, P.; Ballweg, D. M.; LaBonne, C.; Meade, T. J. “Targeted inhibition of Snail family zinc finger transcription factors by oligonucleotide-Co(III) Schiff base conjugate” Proc. Nat. Acad. Sci. 2009, 106, 13667-13672.
Lee, J.; Burdette, J. E.; MacRenaris, K. W.; Mustafi, D.; Woodruff, T. K.; Meade, T. J. “Rational design, synthesis, and biological evaluation of progesterone modified MRI contrast agents” Chem. Biol. 2007, 14, 824-834.
Lee, J.; Zylka, M. J.; Anderson, D. J.; Burdette, J. E.; Woodruff, T. K.; Meade, T. J. “A Steroid-Conjugated Contrast Agent for Magnetic Resonance Imaging of Cell Signaling.” J. Am. Chem. Soc. 2005, 127, 13164-13166.
Lee, J.; Jin, M.; Kang, S-U.; Kim, S. Y.; Lee, J.; Shin, M.; Hwang, J.; Cho, S.; Choi, Y-S.; Choi, H-K.; Kim, S-E.; Suh, Y-G.; Lee, Y-S.; Kim, Y-H.; Ha, H-J.; Toth, A.; Pearce, L. V.; Tran, R.; Szabo, T.; Welter, J. D.; Lundberg, D. J.; Wang, Y.; Lazar, J. ; Pavlyukovets, V. A.; Morgan, M. A.; Blumberg, P. M. “Analysis of structure-activity relationships for the 'B-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino) benzyl]-thiourea analogues as TRPV1 antagonists.” Bioorg. Med. Chem. Lett.2005, 15, 4143-4150.
Lee, J.; Kim, S.Y.; Lee, J.; Kang, M.; Kil, M-J.; Choi, H-K.; Jin, M-K.; Wang, Y.; Toth, A.; Pearce, L.V.; Lundberg, D. J.; Tran, R.; Blumberg, P. M. “Analysis of structure activity relationships with the N-(3-acyloxy-2-benzylpropyl)-N-[4-(methylsulfonylamino)benzyl] thiourea template for vanilloid receptor 1 antagonism.” Bioorg. Med. Chem. 2004, 12, 3411-3420.
Lee, J.; Kang, S-U.; Choi, H-K.; Lee, J.; Lim, J-O.; Kil, M-J.; Jin, M-K.; Kim, K-P.; Sung, J-H.; Chung, S-J; Ha, H-J.; Kim, Y-H.; Pearce, L.V.; Tran, R.; Lundberg, D. J.; Wang, Y.; Toth, A.; Blumberg, P. M. “Analysis of structure activity relationships for the a-region of N-(3-acyloxy-2-benzylpropyl)-N-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: discovery of an N-hydroxythiourea analogue with potent analgesic activity.” Bioorg. Med. Chem. Lett. 2004, 14, 2291-2297.
Lee, J.; Kim, S.Y.; Park, S.; Lim, J-O.; Kim, J-M.; Kang, M.; Lee, J.; Kang, S-U.; Choi, H-K.; Jin, M-K.; Welter, J. D.; Szabo, T.; Tran, R.; Pearce, L. V.; Toth, A.; Blumberg, P. M. “Structure-activity relationships of simplified resiniferatoxin analogues with potent VR1 agonism elucidates an active conformation of RTX for VR1 binding.” Bioorg. Med. Chem.2004, 12, 1055-1069.
Park, H-G.; Choi, J-Y.; Choi, S-H.; Park, M-K.; Lee, J.; Suh, Y-G.; Cho, H.; Oh, U.; Lee, J.; Kang, S-U.; Lee, J.; Kim, H-D.; Park, Y-H.; Jeong, Y.S.; Choi, J. K.; Jew, S-S. “N-4-Substituted-benzyl-N-tert-butylbenzyl thioureas as vanilloid receptor ligands: investigation on the role of methanesulfonamido group in antagonistic activity.” Bioorg. Med. Chem. Lett. 2004, 14, 787-791.
Wang, Y.; Toth, A.; Tran, R.; Szabo, T.; Welter, J. D.; Blumberg, P. M.; Lee, J.; Kang, S-U.;Lim,J-O.;Lee,J “High Affinity of Partial Agonists of Vanilloid Receptor.” Mol. Pharmacol. 2003, 64, 325-334.
Lee, J.; Lee, J.; Kang, M.; Shin, M-Y.; Kim, J-M.; Kang, S-U.; Lim, J-O.; Choi, H-K.; Suh, Y-G.; Park, H-G.; Oh, U.; Kim, H-D.; Park, Y-H.; Ha, H-J.; Kim, Y-H.; Toth, A.; Wang, Y.; Tran, R.; Pearce, L. V.; Lundberg, D. J.; Blumberg,P.M.“N-(3-Acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino) benzyl] thiourea Analogues: Novel Potent and High Affinity Antagonist and Partial Antagonists of the Vanilloid Receptor.” J. Med. Chem. 2003, 46, 3116-3126.
Wang, Y; Szabo, T; Welter, J.D.; Toth, A.; Tran, R.; Lee, J.; Kang, S-U.; Suh, Y-G.; Blumberg, P. M.; Lee, J. “High Affinity Antagonists of the Vanilloid Receptor.” Mol. Pharmacol. 2002, 62, 947-956.
Lee, J.; Lee, J.; Kang, M. S.; Kim, K. P.; Chung, S. J.; Blumberg, P. M.; Yi, J. B.; Park, Y. H. “Phenolic Modification as an Approach to Improve the Pharmacology of the 3-Acyloxy-2-benzylpropyl Homovanillic Amides and Thioureas, a Promising Class of Vanilloid Receptor Agonist and Analgesics.” Bioorg. Med. Chem. 2002, 10, 1171-1179.
Lee, J.; Lee, J.; Szabo, T.; Gonzalez, A. F.; Welter, J. D.; Blumberg, P. M. “N-(3-Acyloxy-2-benzylpropyl)-N-Dihydroxy Tetrahydrobenzazepine and Tetrahydroisoquinoline Thiourea Analogues as Vanilloid Receptor Ligands.” Bioorg. Med. Chem. 2001, 9, 1713-1720.
Lee, J.; Lee, J.; Kim, J.; Kim, S.Y.; Chun, M. W.; Cho, H.; Hwang, S. W.; Oh, U.; Park, Y. H.; Marquez, V. E.; Beheshti, M.; Szabo, T.; Blumberg, P. M.“N-(3-Acyloxy-2-benzylpropyl)-N-(4-hydroxy-3-methoxy benzyl)thiourea Derivatives as Potent Vanilloid Receptor Agonists and Analgesics.” Bioorg. Med. Chem. 2001, 9, 19-32.
Lee, J.; Park, S. U.; Kim, J. Y.; Kim, J. K.; Lee, J.; Oh, U.; Marquez, V. E.; Beheshti, M.; Wang, Q. J.; Modarres, S.; Blumberg, P.M. “N-Acyloxy-2-phenalkylpropyl Amides and Esters of Homovanillic Acid as Novel Vanilloid receptor Agonists.” Bioorg. Med. Chem. Lett. 1999, 9, 2909-2914.
Chun, K. S.; Sohn, Y; Kim, H. S.; Kim, O. H.; Park, K. K; Lee, J. M.; Lee, J.; Lee, J; Moon, A; Lee, S. S.; Surh, Y. J. “Anti-tumor Promoting Potential of Naturally Occurring Diarylheptanoids Stucturally Related to Curcumin.” Mutat. Res. 1999, 428, 49-57.
Lee, J.; Lee, J. “A Facile and Practical Synthesis of Capsazepine, A Vanilloid Receptor Antagonist.” Synthetic Commun.1999, 29, 4127-40.
Kim EJ, Jeon HB, Kang MJ,* Lee J* "Dynamic imaging of lipid droplets in cells and tissues by using dioxaborine barbiturate-based fluorogenic probes"
Anal. Chem. 2024, 96, 8356-8364. (*co-corresponding authors)
The Atomwise AIMS Program (Wallack et al.) "AI is a viable alternative to high throughput screening: a 318-target study" Sci. Rep. 2024, 14, 7526.
2023
Park JE**, Lee J**, Ok S, Byun S, Yoon SE, Kim YJ, Kang MJ "Wg/Wnt1 and Erasp link ER stress to proapoptotic signaling in an autosomal dominant retinitis pigmentosa model" Exp. Mol. Med. 2023, 55, 1544-1555 (**co-first authors)
Song D**, Lee JY**, Park EC, Choi NE, Nam HY, Seo J*, Lee J* "Structure-activity relationship analysis of activity-based probes targeting HTRA family of serine proteases" Bioorg. Med. Chem. Lett. 2023, 87, 129259 (**co-first authors, *co-corresponding authors)
2022
Choi NE, Kim EJ, Lee J. "A fluorescent molecular rotor for the in situ imaging of latent fingerprints" RSC Adv. 2022, 12, 33180-33186
Kim S**, Lee JY**, Choi J, Nam HY, Seo J*, Lee J* "Structure-activity relationship of mitochondria-targeting peptoids" Pept. Sci. 2022, 114, e24239. (**co-first authors & *co-corresponding authors)
2021
Manh NV, Hoang V, Ngo VTH, Ann J, Jang T-H, Ha J-H, Song JY, Ha H-J, Kim H, Kim Y-H, Lee J, Lee J. "Discovery of highly potent human glutaminyl cyclase (QC) inhibitors as anti-Alzheimer's agents by the combination of pharmacophore-based and structure-based design" Eur.J.Med.Chem. 2021, 226, 113819.
Kim TH, Morshed MN, Londhe AM, Lim JW, Jung SY, Yang H, Cho S, Cho SJ, Hwang H, Lim SM, Lee JY, Lee J*, Pae AN* "The translocator protein ligands as mitochondrial functional modulators for the potential anti-Alzheimer agents" J. Enzyme Inhib. Med. Chem. 2021, 36, 831-846 (*co-corresponding authors)
Choi NE, Lee JY, Park EC, Lee JH, Lee J. "Recent advances in organelle-targeted fluorescent probes" Molecules 2021, 26, 217.
2020
Nam HY, Choi J, Kumar SD, Nielsen JE, Kyeong M, Wang S, Kang D, Lee Y, Lee J, Yoon MH, Hong S, Lund R, Jenssen H, Shin SY, Seo J. "Helicity modulation improves selectivity of antimicrobial peptoids" ACS Infect. Dis. 2020, 6, 2732-2744
Nam, H.Y.**; Song, D.**; Eo, J.**; Choi, N-E.; Hong, J-A.; Hong, K.T.; Lee, J-S.; Seo, J.*; Lee, J.* "Activity-based probes for the high temperature requirement A serine proteases." ACS Chem. Biol. 2020, 15, 2346-2354 (**co-first authors and *co-corresponding authors)
Lim JW, Lee J,* Pae AN.* "Mitochondrial dysfunction and Alzheimer's disease: prospects for therapeutic intervention." BMB Rep. 2020, 53, 47-55. (*co-corresponding authors)
Kim S, Nam HY, Lee J,* Seo J.* "Mitochondrion-Targeting Peptides and Peptidomimetics: Recent Progress and Design Principles." Biochemistry 2020, 59, 270-284. (*co-corresponding authors)
2019
Hoang VH, Ngo VTH, Cui M, Manh NV, Tran PT, Ann J, Ha HJ, Kim H, Choi K, Kim YH, Chang H, Macalino SJY, Lee J, Choi S, Lee J. "Discovery of Conformationally Restricted Human Glutaminyl Cyclase Inhibitors as Potent Anti-Alzheimer's Agents by Structure-Based Design." J. Med. Chem. 2019, 62, 8011-8027.
Yoon S, Kim SE, Kim JH, Yoon I, Tran PT, Ann J, Kim C, Byun WS, Lee S, Kim S, Lee J,* Lee J.* "Structure-activity relationship of leucyladenylate sulfamate analogues as leucyl-tRNA synthetase (LRS)-targeting inhibitors of Mammalian target of rapamycin complex 1 (mTORC1)." Bioorg. Med. Chem. 2019, 27, 1099-1109. (*co-corresponding authors)
2018
Elkamhawy A, Park JE, Hassan AHE, Pae AN, Lee J, Paik S, Park BG, Roh EJ. "Pyrazinyl ureas revisited: 1-(3-(Benzyloxy)pyrazin-2-yl)-3-(3,4-dichlorophenyl)urea, a new blocker of Aβ-induced mPTP opening for Alzheimer's disease." Eur. J. Med. Chem. 2018, 157, 268-278.
Yoon S, Zuo D, Kim JH, Yoon I, Ann J, Kim SE, Cho D, Kim WK, Lee S, Lee J, Kim S, Lee J. " Discovery of novel leucyladenylate sulfamate surrogates as leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors." Bioorg. Med. Chem. 2018, 26, 4073-4079.
Ngo, V.T.H.; Hoang, V.; Tran, P.; Van Manh N.; Ann, J.; Kim, E.; Cui, M.; Choi, S.; Lee, J.; Kim, H.; Ha, H.; Choi, K.; Kim, Y.; Lee, J. “Potent human glutaminyl cyclase inhibitors as potential anti-Alzheimer's agents: Structure-activity relationship study of Arg-mimetic region” Bioorg. Med. Chem. 2018, 26, 3133-3144
Nam, H.Y.*; Hong, J.A.*; Choi, J.; Shin, S.; Cho, S.K.; Seo, J.; Lee, J. "Mitochondria-targeting peptoids" Bioconj. Chem. 2018, 29, 1669-1676. (*Co-first authors)
Hong, J.A.; Kim, M.J.; Eoh, J.; Lee, J. “A turn-on fluorescent probe for live cell imaging of biothiols” Bull. Kor. Chem. Soc. 2018, 39, 425-426.
Ngo, V.T.H.; Hoang, V.; Tran, P.; Ann, J.; Cui, M.; Park, G.; Choi, S.; Lee, J.; Kim, H.; Ha, H.; Choi, K.; Kim, Y.; Lee, J. “Potent human glutaminyl cyclase inhibitors as potential anti-Alzheimer's agents: Structure-activity relationship study of Arg-mimetic region” Bioorg. Med. Chem. 2018, 26, 1035-1049.
Kim, S.M.; Lee, M.; Lee, S.Y.; Lee, S.M.; Kim, E.J.; Kim, J.S.; Ann, J.; Lee, J.; Lee, J. “Synthesis and biological evaluation of 3-(2-aminoethyl) uracil derivatives as gonadotropin-releasing hormone (GnRH)receptor antagonists” Eur. J. Med. Chem. 2018, 145, 413-424.
Elkamhawy, A.; Park, J.E.; Hassan, A.H.; Pae, A.N.; Lee, J.; Park, B.G.; Roh, E.J. “Synthesis and evaluation of 2-(3-arylureido)pyridines and 2-(3-arylureido)pyrazines as potential modulators of Aβ-induced mitochondrial dysfunction in Alzheimer's disease.” Eur. J. Med. Chem. 2018, 144, 529-543.
Lee, J.; Kang, D.; Choi, J.; Huang, W.; Wadmen, M.; Barron, A.E.; Seo, J. “Effect of side chain hydrophobicity and cationic charge on antimicrobial activity and cytotoxicity of helical peptoids” Bioorg. Med. Chem. Lett. 2018, 28, 170-173.
Ha, H.; Kang, D.W.; Kim, H.M.; Kang, J.M.; Ann, J.; Hyun, H.J.; Lee, J.H.; Kim, S.H.; Kim, H.; Choi, K.; Hong, H.S.; Kim, Y.H.; Jo, D.G.; Lee, J.; Lee, J. “Discovery of an Orally Bioavailable Benzofuran Analogue that Serves as a β-amyloid Aggregation Inhibitor for the Potential Treatment of Alzheimer's Disease.” J. Med. Chem. 2018, 61, 396-402.
2017
Park, J.E.; Elkamhawy, A.; Hassan, A.H.; Pae, A.N.; Lee, J.; Paik, S.; Park, B.G.; Roh, E.J. “Synthesis and evaluation of new pyridyl/pyrazinyl thiourea derivatives: Neuroprotection against amyloid-β-induced toxicity.” Eur. J. Med. Chem. 2017, 141, 322-334.
Kim, T.H.; Son, W.S.; Morshed, M.N.; Londhe, A.M.; Jung, S.Y.; Park, J.; Park, W.K.; Lim, S.M.; Park, K.D.; Cho, S.J.; Jeong, K.S.; Lee, J.*; Pae, A.N.* “Discovery of thienopyrrolotriazine derivatives to protect mitochondrial function against Aβ-induced neurotoxicity.” Eur. J. Med. Chem. 2017, 141, 240-256 (*co-corresponding authors)
Hong, J.A.; Choi, N.E.; La, Y.K.; Nam, H.Y.; Seo, J.; Lee, J. “Development of a smart activity-based probe to detect subcellular activity of asparaginyl endopeptidase in living cells.” Org. Biomol. Chem. 2017, 15, 8018-8022.
Park, I.; Viswanath, A.N.I.; Park, B.G.; Jung, S. Y.; Park, K. D.; No, K. T.; Lee, J.; Pae, A.N. “Discovery of Non-Peptidic Small Molecule Inhibitors of Cyclophilin D as Neuroprotective Agents in Ab-induced Mitochondrial Dysfunction” J. Comput. Aided Mol. Des. 2017, 31, 929-941.
Yoon, S.; Kim, J.H.; Koh, Y.; Tran, P.T.; Ann, J.; Yoon, I.; Jang, J.; Kim, W.K.; Lee, S.; Lee, J.; Kim, S.; Lee, J. "Discovery of simplified leucyladenylate sulfamates as novel leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors." Bioorg. Med. Chem. 2017, 25, 4145-4152
Elkamhawy, A.; Park, J.E.; Hassan, A.H.; Pae, A.N.; Lee, J.; Park, B.G.; Paik, S.; Do, J.; Park, J.H.; Park, K.D.; Moon, B.; Park, W.K.; Cho, H.; Jeong, D.Y.; Roh, E.J. "Design, synthesis, biological evaluation and molecular modelling of 2-(2-aryloxyphenyl)-1,4-dihydroisoquinolin-3(2H)-ones: A novel class of TSPO ligands modulating amyloid-β-induced mPTP opening." Eur. J. Pharm. Sci. 2017, 104, 366-381
Hoang, V.; Tran, P.; Cui, M.; Ngo, V.T.H.; Park, J.; Choi, S.; Lee, J.; Choi, K.; Cho, H.; Kim, H.; Ha, H.; Hong, H.; Kim, Y.; Lee, J. “Discovery of Potent Human Glutaminyl Cyclase Inhibitors as Anti-Alzheimer’s Agent Based on Rational Design” J. Med. Chem. 2017, 60, 2573-2590
Elkamhawy, A.; Park, J.E.; Hassan, A.H.; Ra, H.; Pae, A.N.; Lee, J.; Park, B.G.; Moon, B.; Park, H.M.; Roh, E.J. "Discovery of 1-(3-(benzyloxy)pyridin-2-yl)-3-(2-(piperazin-1-yl)ethyl)urea: A new modulator for amyloid beta-induced mitochondrial dysfunction." Eur. J. Med. Chem. 2017, 128, 56-69
Kim, T.H.; Yang, H.Y.; Park, B.G.; Jung, S.Y.; Park, J.H.; Park, K.D.; Min, S.J.; Tae, J.; Yang, H.; Cho, S.; Song, H.; Mook-Jung, I.; Lee, J.*; Pae, A.N.* “Discovery of Benzimidazole Derivatives as Modulators of Mitochondrial Function: A Potential Treatment for Alzheimer’s Disease” Eur. J. Med. Chem. 2017, 125, 1172-1192 (*co-corresponding authors)
2016
Yoon, S.; Kim, J.H.; Kim, S.; Jang, J.; Kim, S.; Moon, H.; Kim, W.; Lee, S.; Lee, J.; Kim, S.; Lee, J. “Discovery of leucyladenylate sulfamates as novel leucyl-tRNA (LRS)-targeted mTORC1 inhibitors” J. Med. Chem. 2016, 59, 10322-10328.
Kim, SM; Lee, M; Lee, SY; Park, E; Lee, SM; Kim, EJ; Han, MY; Yoo, T; Ann, J; Yoon, S; Lee, J; Lee, J "Discovery of an Orally Bioavailable Gonadotropin-Releasing Hormone Receptor Antagonist." J. Med. Chem. 2016, 59, 9150-9172
Cho, N.C.; Seo, S.H.; Kim, D.;Shin, J.S.; Ju, J.; Seong, J.; Seo, S.H.; Lee, J.; Lee, K.T.; Kim, Y.K.; No, K.T.; Pae, A.N. "Pharmacophore-based virtual screening, biological evaluation and binding mode analysis of a novel protease-activated receptor 2 antagonist" J. Comput .Aided Mol. Des. 2016, 8, 625-37.
La, Y.K.; Hong, J.A.; Jeong, Y.J.; Lee, J. " A 1,8-naphthalimide-based chemosensor for dual-mode sensing: Colorimetric and fluorometric detection of multiple analytes" RSC Adv. 2016, 6, 84980-84105
Yoon, S; Kim, J. H.; Yoon, I.; Kim, C.; Kim, S.E.; Koh, Y.; Jeong, S.J.; Lee, J.; Kim, S.; Lee, J. "Discovery of (S)-4-isobutyloxazolidin-2-one as a novel leucyl-tRNA synthetase (LRS)-targeted mTORC1 inhibitor." Bioorg. Med. Chem. Lett. 2016, 26, 3038-3041
Lee, J. "Mitochondrial drug targets in neurodegenerative diseases", Bioorg. Med. Chem. Lett. 2016, 26, 714-720
Lee, H.R.; Farhanullah; Lee, J.; Jajoo, R.; Kong, S.Y.; Shin, J.Y.; Kim, J.O.; Lee, J.; Lee J.; Kim, H.J. “Discovery of a Small Molecule that Enhances Astrocytogenesis by Activation of STAT3, SMAD1/5/8, and ERK1/2 via Induction of Cytokines in Neural Stem Cells.” ACS Chem. Neurosci. 2016, 7, 90-99
2015
Cho, N.C.; Cha, J.H.; Kim, H.; Kwak, J.; Kim, D.; Seo, S.H.; Shin, J.S.; Kim, T.; Park, K.D.; Lee, J.; No, K.T.; Kim, Y.K.; Lee, K.T.; Pae, A.N. “Discovery of 2-aryloxy-4-amino-quinazoline derivatives as novel protease-activated receptor 2 (PAR2) antagonists.” Bioorg. Med.Chem. 2015, 23, 7717-7727
Choi K, Lim KS, Shin J, Kim SH, Suh YG, Hong HS, Kim H, Ha HJ, Kim YH, Lee J, Lee J. "6-Phenoxy-2-phenylbenzoxazoles, novel inhibitors of receptor for advanced glycation end products (RAGE)" Bioorg. Med. Chem. 2015, 23, 4919-4935
La, Y. K.; Choi, N. E.; Chung, S.; Lee, J. "Thiophene‐substituted Aza‐BODIPYs as Near‐Infrared Fluorophores" Bull. Kor. Chem. Soc. 2015, 36, 1747-1748
Lee J, Huang W, Broering JM, Barron AE, Seo J. "Prostate tumor specific peptide-peptoid hybrid prodrugs" Bioorg. Med. Chem. Lett. 2015, 25, 2849-2952
Nam M, Kim T, Kwak J, Seo SH, Ko MK, Lim EJ, Min SJ, Cho YS, Keum G, Baek DJ, Lee J,* Pae AN.* "Discovery and biological evaluation of tetrahydrothieno[2,3-c]pyridine derivatives as selective metabotropic glutamate receptor 1 antagonists for the potential treatment of neuropathic pain" Eur. J. Med. Chem. 2015, 97, 245-258 (*co-corresponding author)
Cho GH, Kim T, Son WS, Seo SH, Min SJ, Cho YS, Keum G, Jeong KS, Koh HY, Lee J,* Pae AN.* "Synthesis and biological evaluation of aryl isoxazole derivatives as metabotropic glutamate receptor 1 antagonists: a potential treatment for neuropathic pain" Bioorg. Med. Chem. Lett. 2015, 25,1324-1328 (*co-corresponding author)
2014
Elkamhawy A, Lee J, Park BG, Park I, Pae AN, Roh EJ. "Novel quinazoline-urea analogues as modulators for Aβ-induced mitochondrial dysfunction: design, synthesis, and molecular docking study" Eur. J. Med. Chem. 2014, 84, 466-75
2013
Choi, M. J.; Thorat, D. A.; Jang, J. W.; Yang, H.; No, E. S.; Kim, S. J.; Lee, J.; Choo, H.; Lee, C. S.; Ko, S.Y.; Lee, J.; Nam, G. S.; Pae, A. N.“Synthesis and biological evaluation of aryloxazole derivatives as vascular disrupting agents for cancer therapy” J. Med. Chem. 2013, 56, 9008-9018
Yoon, H.J.; Kong, S.Y; Park, M.H.; Cho, Y.; Kim, S.E.; Shin, J.Y.; Jung, S.;Lee, J.; Farhanullah; Kim, H.J.; Lee, J. “Structure-activity relationship of human glutaminyl cyclase inhibitors having an N-(5-methyl-1H-imidazol-1-yl)propyl thiourea template” Bioorg. Med. Chem. 2013, 21, 7165-7174
Morell, M.; Nguyen, Duc T.; Willis, A.L.; Syed, S.; Lee, J.; Deu, E.; Deng, Y.; Xiao, J.; Turk, B.E.; Jessen, J.R.; Weiss, S.J.; Bogyo, M.“Coupling Protein Engineering with Probe Design To Inhibit and Image Matrix Metalloproteinases with Controlled Specificity.” J. Am. Chem. Soc. 2013, 135, 9139-9148
Tran, P.T.; Hoang, V.H.; Thorat, S.A.; Kim, S.E.; Ann, J.; Chang, Y.J.; Nam, D.W.; Song, H.; Mook-Jung, I.; Lee, J.; Lee, J. “Structure-activity relationship of human glutaminyl cyclase inhibitors having an N-(5-methyl-1H-imidazol-1-yl)propyl thiourea template” Bioorg. Med. Chem. 2013, 13, 3821-3830
Kang, B.; Chung, S.; Ahn, Y.D.; Lee, J.; Seo, J. “Porphyrin-Peptoid Conjugates: Face-to-Face Display of Porphyrins on Peptoid Helices” Org. Lett. 2013, 15, 1670-1673
Yang, H.Y.; Tae, J.; Seo, Y.W.; Kim, Y.J.; Im, H.Y.; Choi, G.D.; Cho, H.;Park, W-K.; Kwon, O.S.; Cho, Y.S.; Ko, M.; Jang, H.; Choi, K.; Kim, C-H.; Lee, J.*; Pae, A.N.* “Novel Pyrimidoazepine analogs as serotonin 5-HT2A and 5-HT2C receptor ligands for the treatment of obesity” Eur. J. Med. Chem. 2013, 63, 558-569 (*co-corresponding author)
Kim, Y.S.; Jung, S.H.; Park, B.G.; Ko, M.K.; Jang, H.S.; Choi, K.; Baik, J.H.; Lee, J.; Lee, J.K.; Pae, A.N.; Cho, Y.S.; Min, S.J. "Synthesis and evaluation of oxime derivatives as modulators for amyloid beta-induced mitochondrial dysfunction" Eur. J. Med. Chem. 2013, 62, 71-83
Lee, J.* Bogyo, M.* “Target Deconvolution Techniques in Modern Phenotypic Profiling” Curr. Opin. Chem. Biol. 2013, 17, 118-126 (*co-corresponding author)
Edgington, L.E.; Verdoes, M.; Ortega, A.; Withana, N.P.; Lee, J.; Syed, S.; Bachmann, M.H.; Blum, G.; Bogyo, M. “ Functional Imaging of Legumain in Cancer Using a New Quenched Activity-Based Probe” J. Am. Chem. Soc. 2013, 135, 174-182
2012
Kim, J; Lee, J; Moon, B; Mook-Jung, I; Nam, G; Keum, G; Pae, A.N.; Choo, H. “Pyridyl-urea Derivatives as Blockers of Abeta induced mPTP Opening for Alzheimer’s Disease” Bull. Korean Chem. Soc. 2012, 33, 3887-3889
Lee, J “Cobalt(III) Complexes as Novel Matrix Metalloproteinase-9 Inhibitors” Bull. Korean Chem. Soc. 2012, 33, 2762-2764
Cho, Y.; Kim, M.S.; Kim, H.S.; Ann, J.; Lee, J.; Pearce, L.V.; Pavlyukovets, V.A.; Morgan, M. A.; Blumberg, P.M.; Lee, J. “The SAR analysis of TRPV1 agonists with the a-methylated B-region” Bioorg. Med. Chem. Lett. 2012, 22, 5227-5231.
Lee, J.*; Bogyo, M.* “Synthesis and evaluation of aza-peptidyl inhibitors of the lysosomal asparaginyl endopeptidase, legumain” Bioorg. Med. Chem. Lett. 2012, 22, 1340-1343. (*co-corresponding author)
1999-2011
Ewald, S. E.; Engel, A.; Lee, J.; Wang, M.; Bogyo, M.; Barton, G. M. “ Nucleic acid recognition by Toll-like receptors is coupled to processing by cathepsins and asparagine endopeptidase.” J. Exp. Med. 2011, 208, 643-651.
Lee, J.; Bogyo, M. “Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain” ACS Chem.Biol. 2010, 5, 233-243.
Harney, A. S.; Lee, J.; Manus, L. M.; Wang, P.; Ballweg, D. M.; LaBonne, C.; Meade, T. J. “Targeted inhibition of Snail family zinc finger transcription factors by oligonucleotide-Co(III) Schiff base conjugate” Proc. Nat. Acad. Sci. 2009, 106, 13667-13672.
Lee, J.; Burdette, J. E.; MacRenaris, K. W.; Mustafi, D.; Woodruff, T. K.; Meade, T. J. “Rational design, synthesis, and biological evaluation of progesterone modified MRI contrast agents” Chem. Biol. 2007, 14, 824-834.
Lee, J.; Zylka, M. J.; Anderson, D. J.; Burdette, J. E.; Woodruff, T. K.; Meade, T. J. “A Steroid-Conjugated Contrast Agent for Magnetic Resonance Imaging of Cell Signaling.” J. Am. Chem. Soc. 2005, 127, 13164-13166.
Lee, J.; Jin, M.; Kang, S-U.; Kim, S. Y.; Lee, J.; Shin, M.; Hwang, J.; Cho, S.; Choi, Y-S.; Choi, H-K.; Kim, S-E.; Suh, Y-G.; Lee, Y-S.; Kim, Y-H.; Ha, H-J.; Toth, A.; Pearce, L. V.; Tran, R.; Szabo, T.; Welter, J. D.; Lundberg, D. J.; Wang, Y.; Lazar, J. ; Pavlyukovets, V. A.; Morgan, M. A.; Blumberg, P. M. “Analysis of structure-activity relationships for the 'B-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino) benzyl]-thiourea analogues as TRPV1 antagonists.” Bioorg. Med. Chem. Lett.2005, 15, 4143-4150.
Lee, J.; Kim, S.Y.; Lee, J.; Kang, M.; Kil, M-J.; Choi, H-K.; Jin, M-K.; Wang, Y.; Toth, A.; Pearce, L.V.; Lundberg, D. J.; Tran, R.; Blumberg, P. M. “Analysis of structure activity relationships with the N-(3-acyloxy-2-benzylpropyl)-N-[4-(methylsulfonylamino)benzyl] thiourea template for vanilloid receptor 1 antagonism.” Bioorg. Med. Chem. 2004, 12, 3411-3420.
Lee, J.; Kang, S-U.; Choi, H-K.; Lee, J.; Lim, J-O.; Kil, M-J.; Jin, M-K.; Kim, K-P.; Sung, J-H.; Chung, S-J; Ha, H-J.; Kim, Y-H.; Pearce, L.V.; Tran, R.; Lundberg, D. J.; Wang, Y.; Toth, A.; Blumberg, P. M. “Analysis of structure activity relationships for the a-region of N-(3-acyloxy-2-benzylpropyl)-N-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: discovery of an N-hydroxythiourea analogue with potent analgesic activity.” Bioorg. Med. Chem. Lett. 2004, 14, 2291-2297.
Lee, J.; Kim, S.Y.; Park, S.; Lim, J-O.; Kim, J-M.; Kang, M.; Lee, J.; Kang, S-U.; Choi, H-K.; Jin, M-K.; Welter, J. D.; Szabo, T.; Tran, R.; Pearce, L. V.; Toth, A.; Blumberg, P. M. “Structure-activity relationships of simplified resiniferatoxin analogues with potent VR1 agonism elucidates an active conformation of RTX for VR1 binding.” Bioorg. Med. Chem.2004, 12, 1055-1069.
Park, H-G.; Choi, J-Y.; Choi, S-H.; Park, M-K.; Lee, J.; Suh, Y-G.; Cho, H.; Oh, U.; Lee, J.; Kang, S-U.; Lee, J.; Kim, H-D.; Park, Y-H.; Jeong, Y.S.; Choi, J. K.; Jew, S-S. “N-4-Substituted-benzyl-N-tert-butylbenzyl thioureas as vanilloid receptor ligands: investigation on the role of methanesulfonamido group in antagonistic activity.” Bioorg. Med. Chem. Lett. 2004, 14, 787-791.
Wang, Y.; Toth, A.; Tran, R.; Szabo, T.; Welter, J. D.; Blumberg, P. M.; Lee, J.; Kang, S-U.;Lim,J-O.;Lee,J “High Affinity of Partial Agonists of Vanilloid Receptor.” Mol. Pharmacol. 2003, 64, 325-334.
Lee, J.; Lee, J.; Kang, M.; Shin, M-Y.; Kim, J-M.; Kang, S-U.; Lim, J-O.; Choi, H-K.; Suh, Y-G.; Park, H-G.; Oh, U.; Kim, H-D.; Park, Y-H.; Ha, H-J.; Kim, Y-H.; Toth, A.; Wang, Y.; Tran, R.; Pearce, L. V.; Lundberg, D. J.; Blumberg,P.M.“N-(3-Acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino) benzyl] thiourea Analogues: Novel Potent and High Affinity Antagonist and Partial Antagonists of the Vanilloid Receptor.” J. Med. Chem. 2003, 46, 3116-3126.
Wang, Y; Szabo, T; Welter, J.D.; Toth, A.; Tran, R.; Lee, J.; Kang, S-U.; Suh, Y-G.; Blumberg, P. M.; Lee, J. “High Affinity Antagonists of the Vanilloid Receptor.” Mol. Pharmacol. 2002, 62, 947-956.
Lee, J.; Lee, J.; Kang, M. S.; Kim, K. P.; Chung, S. J.; Blumberg, P. M.; Yi, J. B.; Park, Y. H. “Phenolic Modification as an Approach to Improve the Pharmacology of the 3-Acyloxy-2-benzylpropyl Homovanillic Amides and Thioureas, a Promising Class of Vanilloid Receptor Agonist and Analgesics.” Bioorg. Med. Chem. 2002, 10, 1171-1179.
Lee, J.; Lee, J.; Szabo, T.; Gonzalez, A. F.; Welter, J. D.; Blumberg, P. M. “N-(3-Acyloxy-2-benzylpropyl)-N-Dihydroxy Tetrahydrobenzazepine and Tetrahydroisoquinoline Thiourea Analogues as Vanilloid Receptor Ligands.” Bioorg. Med. Chem. 2001, 9, 1713-1720.
Lee, J.; Lee, J.; Kim, J.; Kim, S.Y.; Chun, M. W.; Cho, H.; Hwang, S. W.; Oh, U.; Park, Y. H.; Marquez, V. E.; Beheshti, M.; Szabo, T.; Blumberg, P. M.“N-(3-Acyloxy-2-benzylpropyl)-N-(4-hydroxy-3-methoxy benzyl)thiourea Derivatives as Potent Vanilloid Receptor Agonists and Analgesics.” Bioorg. Med. Chem. 2001, 9, 19-32.
Lee, J.; Park, S. U.; Kim, J. Y.; Kim, J. K.; Lee, J.; Oh, U.; Marquez, V. E.; Beheshti, M.; Wang, Q. J.; Modarres, S.; Blumberg, P.M. “N-Acyloxy-2-phenalkylpropyl Amides and Esters of Homovanillic Acid as Novel Vanilloid receptor Agonists.” Bioorg. Med. Chem. Lett. 1999, 9, 2909-2914.
Chun, K. S.; Sohn, Y; Kim, H. S.; Kim, O. H.; Park, K. K; Lee, J. M.; Lee, J.; Lee, J; Moon, A; Lee, S. S.; Surh, Y. J. “Anti-tumor Promoting Potential of Naturally Occurring Diarylheptanoids Stucturally Related to Curcumin.” Mutat. Res. 1999, 428, 49-57.
Lee, J.; Lee, J. “A Facile and Practical Synthesis of Capsazepine, A Vanilloid Receptor Antagonist.” Synthetic Commun.1999, 29, 4127-40.
